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Cargo receptors can bind to ubiquitylated material or they can be embedded in target organelles, but labile proteins can also feature receptor-like motifs that mediate direct degradation (Gohel et al, 2020

The combination of both anemia and obesity may affect adolescent growth and development, leading to psychological disorders, cognitive dysfunction, impaired motor abilities, altered timing of puberty, and multiple risk of comorbidities such as the metabolic syndrome and type 2 diabetes 55,56

Causes of Haemochromatosis Primary haemochromatosis: genetic disorder causing increased absorption of iron in digestive tract, causing a buildup of iron in the body, especially the liver